Артемизинин 98% имеет какое применение
Artemisinin is one of the most effective drugs to treat malaria resistance. Combination therapy based on artemisinin-based drugs is the most effective and important means to treat malaria at present. In recent years, with the deepening of research, artemisinin has also been found to have other pharmacological effects, such as anti-tumor, treatment of pulmonary hypertension, anti-diabetes, embryonic toxicity, anti-fungal, immune regulation, antiviral, anti-inflammatory, anti-pulmonary fibrosis, antibacterial, cardiovascular and other pharmacological effects.
Свойства: Белый порошок
Source: Extracted from the stems and leaves of Artemisia annua
Molecular formula: C15H22O5
Метод обнаружения: ВЭЖХ
molecular weight: 282.34
Distribution of artemisinin
Artemisinin is mainly extracted directly from artemisinin, or extracted from artemisinin with a higher content of artemisinin, and then semi-synthesized. Although artemisinin is widely distributed in different parts of the world, the content of artemisinin varies greatly with different places, and it has remarkable ecological significance. According to the study, except for parts of China, the content of artemisinin produced in most regions of the world is very low and has no use value.
Artemisinin application field
Artemisinin Anti-malaria
The peroxy bond in artemisinin structure is oxidizing and is an essential antimalarial group. The mechanism of action is that the free groups produced by artemisinin in vivo bind to plasmodium protein and change the membrane structure of plasmodium. After the free group binds to the malarial protein, the double membrane of the mitochondria will burst and eventually fall off, resulting in the destruction of the cell structure and function of the malaria parasite, and the chromatin in the nucleus will also be affected to a certain extent.
Artemisinin Anti-tumor
Artemisinin can regulate the expression of cyclin in tumor cells, enhance the effect of CKIs, and lead to cell cycle arrest. Or it can cause cell apoptosis and inhibit tumor angiogenesis to resist the occurrence and development of tumors.
Artemisinin Treatment of pulmonary hypertension
Pulmonary hypertension (PAH) is a pathophysiological condition characterized by pulmonary artery remodeling and elevated pulmonary artery pressure to a certain limit, which can be a complication or syndrome. Artemisinin is used to treat pulmonary hypertension: it reduces pulmonary artery pressure and improves symptoms in patients with PAH by dilating blood vessels.
Artemisinin Иммунная регуляция
It was found that the dose of artemisinin and its derivatives could inhibit T lymphocyte mitogen well without causing cytotoxicity, thus inducing the proliferation of mouse spleen lymphocytes.
Artemisinin Antifungal
The antifungal action of artemisinin also makes artemisinin exhibit certain antibacterial activity. The study confirmed that artemisinin residue powder and water decoction had strong antibacterial action against Bacillus anthracis, Staphylococcus epidermidis, Coccus catarrhus and Bacillus diphtheriae, and also had certain antibacterial action against Bacillus tuberculosis, Bacillus aeruginosa, Staphylococcus aureus and Bacillus dysenteriae.
Artemisinin Anti-diabetes
Artemisinin causes glucagon-producing alpha cells to “transform” into insulin-producing beta cells. Artemisinin binds to a protein called gephyrin. Gephyrin activates the GABA receptor, the main switch for cell signaling. Subsequently, numerous biochemical reactions change, leading to the production of insulin.
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