4 Значительные преимущества куркумина для здоровья мозга
Что такое curcumin?
Curcumin is a bright orange-yellow compound found in turmeric, which gives curries their distinctive color (and is also often added to yellow mustard). Turmeric has been used as a prescription (grade) for thousands of years and is a revered herb in Ayurvedic medicine. Curcumin is often thought of as an anti-inflammatory prescription that can ease pain and inflammatory responses, but now it’s also finding great potential for optimizing brain health. Recent medical trials have shown that curcumin helps repair depression, anxiety and schizophrenia.
Куркумин is structurally known as a “polyphenol”. Polyphenols are widely distributed in nature and are found in many different plants. In addition to curcumin, several flavonoid-rich herbs have been studied for their potential benefits to brain health, including green tea, grape seed, and pine bark extracts. In general, polyphenols such as curcumin are strong antioxidants, which may play a health-promoting role.
Куркумин and depression
Depression is very difficult to repair, and only about 50% of patients respond to standard medications. Even in patients with optimization, it is usually only partially optimized and accompanied by significant sequelae. For the large number of patients who do not respond well to standard therapies, alternative therapies, especially those with strong reassurance, are needed.
While some other natural remedies, such as St. John’s wort and saffron, also have some healing effects on depression, the new curcumin study strongly suggests that curcumin also has some healing effects on depression and low mood. Interest in curcumin to repair depression is growing as animal models have shown that curcumin has a variety of effects, including normalization of stress response, anti-inflammatory effects, and optimization of neurotransmitter function (including serotonin).
Since 2013, scientists have been conducting medical trials of curcumin to repair depression for the past 10 years. The first medical trials used fairly low doses of curcumin and black pepper extract to enhance absorption. Patients were treated for 5 weeks with a combination of standard prescription and curcumin or placebo, as required. While the results were not significant, the trial did find that curcumin provided faster relief of symptoms than no curcumin.
Further studies explored different formulations and different dosage ranges of curcumin. A very recent meta-analysis combined the results of nine different medical trials; The results show that curcumin can optimize the symptoms of depression. The study even found that the effect size was large, indicating a strong antidepressant effect.
Куркумин and anxiety
While several natural remedies are beginning to show promise in repairing anxiety, including passion flower, lemon flower, zanthoxylum and kava pepper, medical trials of curcumin are also promising. Since many people with depression also have anxiety, many medical trials of curcumin have evaluated both depression and anxiety symptoms.
While not all trials found an anti-anxiety effect, most did. The review concluded that curcumin is helpful for both depression and anxiety.
Curcumin and Alzheimer’s disease
The most common type of dementia is Alzheimer’s disease. The disease comes on very slowly and may develop over a period of 10-20 years as damage to the brain accumulates.
The earliest symptoms include memory problems, but as the disease progresses, it can be devastating, leaving patients unable to take care of themselves or recognize friends or family.
At present, the main repair method of Alzheimer’s disease may be moderate optimization of function; However, they do not slow the progression of the underlying disease. With more and more people living with dementia worldwide, we need better prevention and repair tools now more than ever.
As with other diseases, some preliminary medical research suggests benefits from natural remedies, including fish oil, citicoline acetylcarnitine, and others. Curcumin also seems to work well in natural remedies.
Blood sugar problems and glucose metabolism disease are closely related to Alzheimer’s disease. Because of the strong association, Alzheimer’s disease has been described as a type 3 carbohydrate-metabolic disease. Curcumin has some benefits in controlling blood sugar, which is one of the drivers of glycometabolic disease.
In addition, Alzheimer’s has typical brain damage that occurs many years later, including amyloid plaques and tau tangles. Curcumin has been shown, at least in animal models, to control the formation of amyloid plaques and reduce the levels of amyloid plaques that have already formed. If these effects are also effective in humans, then curcumin is effective in both prevention and repair.
protect the cardiovascular system
Abnormal platelet aggregation tends to cause the formation of blood clots, and curcumin has been shown to prevent abnormal platelet aggregation by enhancing prostacyclin synthesis and inhibiting thrombin synthesis, thereby improving blood circulation.
At the same time, curcumin may reduce cholesterol and triglyceride levels in the body by reducing the absorption of cholesterol in the gut and increasing the conversion of cholesterol into bile acids in the liver, which can speed up the flow of blood in the cardiovascular system to protect cardiovascular health and protect the brain from the risk of blood clots.
What other properties does curcumin have?
The comfort of curcumin
Curcumin has been shown to be quite reassuring and is generally well tolerated in medical trials. However, two issues are worth highlighting. Curcumin as a supplement in the end how much effect, and a large number of human medical studies have shown that curcumin is not only good for the liver, even for liver disease is also good.
Bioavailability of curcumin
Curcumin is insoluble in water and is generally difficult to absorb in the digestive tract. Therefore, many supplements have some way of increasing absorption. Black pepper extract (piperine), nanoparticles and emulsified products are often used to improve bioavailability. In general, products with proven advantages of enhanced absorption and medical research support are recommended.
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Berry A, Collacchi B, Masella R, Vari R, Cirulli F. Curcuma Longa, a “golden spice” that fights neuroinflammatory responses and cognitive decline – what we’ve learned and what needs to be done. Nutrients. 2021; 13(1):194. Published on 30 April 2021. Doi: 10.3390 / nu13051519
de la Monte SM, Wands JR. Alzheimer’s disease is a Type 3 glycometabolic disease – a review of the evidence. J Diabetes Sci Technol. 2008; 2 (6) : 1101-1113. The doi: 10.1177/193229680800200619
Fusar-Poli L, Vozza L, Gabbiadini A, et al. Curcumin repair of depression: a meta-analysis. Crit Rev Food Sci Nutr. 2020; 60 (18) : 3133-3143. The doi: 10.1080/10408398.2019.1677554
Gagliardi S, Morasso C, Stivaktakis P, et al. Formulation and testing of curcumin: New advances in neurological diseases. Molecules. 2020; 25(20):4649. Published November 18, 2020. Doi: 10.3390 / molecules25225389
Gareri P, Castagna A, Cotroneo AM, Putignano S, De Sarro G, Bruni AC. The role of citicoline in cognitive impairment: prescription characteristics, possible advantages, and doubts about a new perspective on old prescriptions [Published revisions in clinical Interv Aging. 2015; 10:165 in the discussion]. Clin Interv Aging. 2015; 10:1421-1429. Posted on September 3, 2015. Doi: 10.2147 / CIA. S87886
Ghazizadeh J, Sadigh-Eteghad S, Marx W, et al. Effects of balsam flower on depression and anxiety in medical trials: a systematic review and meta-analysis. Phytother Res. 2021; 35(12):6690-6705. doi:10.1002/ptr.7252
The role of natural agents in schizophrenia: a systematic review. J Altern Complement Med.
Hosseininasab M, Zarghami M, Mazhari S, et al. Nanocurcumin as an adjunct to antipsychotic medications for the repair of negative symptoms in patients with chronic schizophrenia: a randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol. 2021; 41 (1) : 25-30. Doi: 10.1097 / JCP. 0000000000001324
Jakobsen JC, Katakam KK, Schou A, et al. Selective serotonin reuptake control versus placebo in patients with major depressive disorder. Systematic review of meta-analysis and sequential analysis of trials [Publish corrections to published revisions published in BMC Psychiatry discussion. May 3, 2017; 17(1):162]. BMC Psychiatry. 2017; 17 (1) : 58.
Janda K, Wojtkowska K, Jakubczyk K, Antoniewicz J, Skonieczna- Shaydecka K. Research progress of passionflower in neuropsychiatric diseases: a systematic review. Nutrients. 2020; 12(12):3672. Published December 19, 2020. Doi: 10.3390 / nu12123894
Kaufmann FN, Gazal M, Bastos CR, Kaster MP, Ghisleni G. Overview of potential mechanisms, premedical, and medical outcomes of curcumin in depression. Eur J Pharmacol. 2016; 784:192-198. Doi: 10.1016 / j. jphar. 2016.05.026
Effects of curcumin on cognitive function and inflammatory response status in patients with schizophrenia: a double-blind, placebo-controlled pilot trial. J Clin Psychopharmacol. 2021; 41 (1) : 25-30. Doi: 10.1097 / JCP. 0000000000001324
Lee BS, Bhatia T, Chaya CT, Wen R, Taira MT, Lim BS. Autoimmune hepatitis associated with turmeric ingestion. ACG Case Rep J. 2020; 7(3):e00320. Published on March 16, 2020. Doi: 10.14309 / CRJ. 0000000000000320
Lopresti AL. Curcumin for the repair of neuropsychiatric disorders: a review of in vitro, animal, and human studies. J Psychopharmacol. 2017; 31 (3) : 287-302. The doi: 10.1177/0269881116686883
Luber RP, Rentsch C, Lontos S, et al. Liver injury caused by turmeric: report of 2 cases. Case Reports Hepatol. 2019; 2019:6741213. Published on April 28, 2019. Doi: 10.1155/2019/7861297
Matias JN, Achete G, Campanari GSDS, et al. Systematic review of the antidepressant effects of curcumin: beyond the monoamine theory. Aust N Z J Psychiatry. 2021; 55 (5) : 451-462. The doi: 10.1177/0004867421998795
Miodownik C, Lerner V, Kudkaeva N, et al. Nanocurcumin as an adjunct to antipsychotic medications to repair negative symptoms in patients with chronic schizophrenia: a randomized, double-blind, placebo-controlled study. Clin Neuropharmacol. 2019; 42 (4) : 117-122. The doi: 10.1097 / WNF. 0000000000000344
Ng QX, Venkatanarayanan N, Ho CY. Medical use of Hypericum perforatum in depression: a meta-analysis. J Affect Disord. 2017; 210:211-221. Doi: 10.1016 / j.j AD. 2016.12.048
The role of curcumin in depression: potential mechanisms of action and current evidence – a narrative review. Front Psychiatry. 2020; 11:572533. Posted on November 27, 2020. Doi: 10.3389 / fpsyt. 2020.572533
Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Research progress of herbal remedies for depression, anxiety and insomnia. Eur Neuropsychopharmacol. 2011; 21 (12) : 841-860. The doi: 10.1016 / j. uroneuro. 2011.04.002
Small GW, Siddarth P, LiZ et al. “Effects of a bioavailable form of curcumin on memory and brain amyloid and Dow proteins in non-dementia adults: a double-blind, placebo-controlled 18-month trial”. Am J Geriatr Psychiatry. 2018; 26 (3) : 266-277. The doi: 10.1016 / j.j agp 2017.10.010
Stati G, Rossi F, Sancilio S, Basile M, Di Pietro R. Hepatotoxicity of turmeric: Unfounded allegations. The RUCAM method was used to assess causality in the cases. Front Pharmacol. 2021; 12:780
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