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The function of Smoke Tree Extract Fisetin

Anti-oxidation

Fisetin is a bioflavonoid antioxidant that can help maintain glutathione levels and mitochondrial function in the presence of oxidative stress. It has the potential to cross the blood-brain barrier, which may help maintain neuronal function.
Fisetin may support the body’s antioxidant arsenal through direct free radical scavenging activity and boosting glutathione levels. In vitro studies show that fisetin may support glutathione, a very active antioxidant naturally occurring in the body, by providing cysteine ​​(a building block of glutathione) to cells or enhancing glutathione synthesis. thione. Fisetin may help regulate the production of many proteins involved in protecting the body from oxidative stress and maintaining redox homeostasis (the balance between the rate of free radical production and the rate of scavenging of various antioxidants).

Antitumor

In recent years, the anti-tumor effect of fisetin has attracted people’s attention. Studies have shown that fisetin can exert anti-tumor effects by inducing tumor cell apoptosis, affecting tumor cell signal transduction pathways, inhibiting tumor cell proliferation, and inhibiting tumor cell migration and invasion.
Fisetin mainly induces tumor cell apoptosis through activating Caspase, downregulating BIRC8 and Bcl2L2, and inhibiting COX-2.
The natural product fisetin can inhibit the growth and spread of tumor cells through multiple pathways. At the same time, fisetin has the characteristics of being widely distributed in nature, having few toxic and side effects, and acting in multiple ways. It is believed that with the continuous deepening of the research on the anti-tumor mechanism of fisetin, it is expected to be used in clinical practice more scientifically and rationally, providing a basis for Human Health Career Services.

Anti-cancer effect

The researchers compounded drug carriers with Rhus extract containing fisetin, xanthophyllin, sulfaterin and rhodinin to obtain a composition with anti-cancer activity. Activity experiments showed that Rhus extract has anti-cancer properties in humans. cells, anti-uterine cancer cells, anti-human skin cancer cells and human colon cancer cells. Its main mechanism is to induce the organ differentiation of cancer cells into normal cells by transforming cancer cell genes.
Fisetin is the most typical active compound among Rhus flavonoid compounds, which can effectively inhibit the proliferation of prostate cancer cells and induce their apoptosis. In human lung cancer cells, fisetin can reduce the production of MMPs by inhibiting MAP kinase and NF-κB pathways. It also promotes the proliferation and apoptosis of breast cancer, cervical cancer, blood cancer and other cells. Therefore fisetin is considered to be an anticancer agent with development potential.