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Description

Beta Arbutin Introduction

Arbutin, also known as arbutin, has a chemical name of 4-hydroxyphenyl-D-glucopyranoside and a relative molecular mass of 272.25. It is a naturally occurring glycoside derived from green plants and is an ingredient in many resistant Freeze-dried plants, such as wheat, pears, and bearberries of the Rhododendron family, are rich in solutes. They appear as white needle-shaped crystals or powders. They are easily soluble in hot water, methanol, ethanol, propylene glycol, and glycerin, and are insoluble in ether, chloroform, and petroleum. Solvents such as ether.

Beta Arbutin, also known as 4-Hydroxyphenyl-beta-D-glucopyranoside, is mainly used to bind to tyrosinase of melanocytes in the skin and inhibit tyrosinase activity. Tyrosinase is a key enzyme for skin melanocytes to synthesize melanin. If its function is inhibited, it cannot produce melanin. The reduction of melanin in the skin has the effect of whitening and light spots, so Arbutin is mainly used in skin whiten and remove black skin spots.

Product Name	Beta Arbutin
CAS No	497-76-7
Latin name	Vaccinium vitis-idaea Linn
Appearance	white powder
Specifications	99.5%
Pakage	1kg/bag, 25kg/drum
Storage	Moisture-roof and avoid light, sealed storage.
Test Method	HPLC

The whitening Mechanism of Arbutin

The content and distribution of melanin are the main factors that determine the depth of skin color. Melanin is produced in melanocytes in the basal layer of the skin epidermis. It is finally formed from tyrosine under the action of tyrosinase through a series of complex biochemical reactions. It is transferred from the basal layer to the outer layer of the epidermis from the inside out through synapses. Color the skin.

Tyrosinase has tyrosine hydroxylase activity (catalyzing tyrosine to produce dopa) and dopa oxidase activity (catalyzing dopa to produce dopaquinone). In the process of melanin formation, it serves as the main rate-limiting enzyme. Its activity determines the amount of melanin formed.

Arbutin is a tyrosinase inhibitor that can effectively inhibit tyrosinase activity without affecting cell proliferation concentration. It competes for the binding of dopa through its direct binding to tyrosinase. site, blocks the synthesis of dopa and dopaquinone, thereby interfering with melanocytes and inhibiting the production of melanin. At the same time, it also has the function of diluting formed melanin, accelerating the decomposition and excretion of melanin, reducing skin pigmentation, and removing spots and freckles.

Mainly Specifications of Beta Arbutin

Beta Arbutin crystal 98% HPLC
Beta Arbutin crystal 99.5% HPLC

Benefits of Beta Arbutin

Beta Arbutin acts as a whitening agent to reduce melanin in the skin.
Beta Arbutin can tighten pores and tighten the skin.
Beta Arbutin also regard as antiseptic and anti-inflammatory ingredients.

Specification (TDS) of β-Arbutin

Analysis Items	Specifications	Methods
Active Ingredients Tests
β-Arbutin	≥99.5%	HPLC
Hydroquinone	≤10ppm	HPLC
Physical Tests
Appearance	White Crystal Powder	Visual
Particle size	95% pass 60mesh	Ch.P 2020 IV<0982>
Melting Point	199~201℃±0.5℃	Ch.P 2020 IV<0612>
Specific Optical Rotation	[a]D20= -64~-66.0°±2°	Ch.P 2020 IV<0621>
pH value (1% solution)	5.0 ~7.0	Ch.P 2020 IV<0631>
Water contents	≤0.50%	GB 5009.3
Total ash	≤0.50%	GB 5009.4
Chemical Tests
Heavy Metals	≤50.00ppm	GB 5009.11
Arsenic <As>	≤3.00ppm	GB 5009.11
Lead <Pb>	≤5.00ppm	GB 5009.12
Cadmium<Cd>	≤2.00ppm	GB 5009.15
Mercury <Hg>	≤1.00ppm	GB 5009.17
Microbiological Tests
Total Bacteria Counts	≤300cfu/g	GB 4789.2
Yeast and Molds	≤10cfu/g	GB 4789.15
Coliforms	≤90MPN/100g	GB 4789.3
Salmonella	Negative	GB 4789.4
Staphylococcus aureus	Negative	GB 4789.10
Shigella	Negative	GB 4789.5

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