Efficacy of Epimedium Manufacturers of Epimedium

무엇 Epimedium

Epimedium is a genus of Berberaceae plant, with more than 50 varieties. The active ingredient has been confirmed to be epimedium, a kind of flavonoside.

Animal or in vitro studies have shown that in addition to anti-inflammatory, anti-osteoporosis and neuroprotective properties, icariin and its derivatives can also increase the synthesis of nitric oxide in the penis, inhibit PDE5 in spongy smooth muscle, enhance neurotrophic effect, enhance smooth muscle proliferation, and reduce the formation of advanced glycosylation end products.

Epimedium, also known as goat horn or three-branchweed, is an herb known for its natural aphrodisiac. It gets its name from sheep that eat the leaves of epimedium growing near fields and become more active and sexually active.

What are the empirical effects of Epimedium?

Beneficial dysfunction

Erectile dysfunction is the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance.

According to the Massachusetts Male Aging Study, up to 52% of men between the ages of 40 and 70 suffer from erectile dysfunction.

During sexual stimulation, nitric oxide (NO) is released from nerve endings and cavernous endothelial cells, and promotes cyclic guanosine phosphate (cGMP) production, the accumulation of cGMP leads to the relaxation of the cavernous muscle and increases penile blood flow.

PDE5 is an enzyme mainly found in the smooth muscle of the spongy body that selectively cuts and degrades cGMP, so “inhibiting PDE5” is considered a viable approach to improve erectile dysfunction.

In vitro studies have found that epimedium extract can exert inhibitory activity on phosphodiesterase type 5 (PDE5), so it can further enhance the role of nitric oxide and help maintain erection.

In addition, animal studies have found that compared with the control group, the supplement of epimedium extract can improve penile function by increasing nitric oxide levels and smooth muscle effect.

Boost testosterone

Testosterone, also known as testosterone, is not only a “male hormone”, but also an important contributor to maintaining the robust metabolic function of a variety of body systems.

Testosterone deficiency, also known as delayed hypogonadism, often occurs in older men.

Hypogonadism can cause a range of signs and symptoms, including decreased libido, erectile dysfunction, reduced ejaculation, loss of body and facial hair, loss of bone density, lean mass loss, increase in body fat, fatigue, weakness, increased anxiety, excessive sweating and anemia.

An animal study found that icariin can inhibit apoptosis of smooth muscle cells in the corpus cavernosum of the penis and increase circulating levels of testosterone compared with mice that did not receive the extract.

Good for maintaining bone mass

Osteoporosis is a disease in which bone mass is low and the structure of bone tissue deteriorates, leading to bone fragility and an increased risk of fracture.

Bone mass continues to accumulate during growth, and around the age of 30 bone reaches its maximum strength and density, known as peak bone mass.

Optimizing peak bone mass may have important implications for preventing current or future fractures, with a 10% increase in peak bone mass reducing the risk of osteoporotic fractures in older adults by 50%.

One animal study found that Epimedium extract (200 mg/kg) can promote bone formation and increase peak bone mass (including the whole body, femur, and vertebral body).

Beneficial cardiovascular function

Coronary heart disease (CHD) is a leading cause of death and disability worldwide. According to the World Health Organization, there were 7.254,000 deaths from coronary heart disease worldwide in 2008 (12.8% of all deaths).

Although the causes of partial or complete cessation of cardiac circulation are different, there is a common pathophysiological feature of myocardial ischemia-reperfusion injury.

Myocardial ischemia-reperfusion injury (ISchemia-reperfusion injury) refers to the myocardial injury caused by the interaction of substances accumulated during ischemia with substances delivered by the subsequent recovery of blood flow.

One study found that compared with the control group, flavonoids of epimedium can improve the total antioxidant capacity, inhibit the irreversible damage of cardiomyocytes caused by myocardial ischemia/reperfusion injury, and maintain the normal function of myocardial tissue.

Beneficial for peripheral nerve regeneration

Peripheral nerve injury is the most common post-traumatic injury, usually following mechanical, chemical or thermal injury, with 300,000 new cases occurring in Europe each year.

The classic symptoms are sensory and motor deficits, which can lead to complete paralysis of the affected limb or the development of intractable neuropathic pain, with devastating effects on the patient’s quality of life.

While there is much knowledge about the mechanisms of injury and regeneration, there are few reliable treatments to ensure full recovery of function.

An animal study showed that Epimedium extract can effectively promote peripheral nerve regeneration and improve damaged nerve function.

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