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Chlorophyll is a fat-soluble green pigment found mostly in green plants and algae that absorbs sunlight and promotes photosynthesis (the synthesis of carbon dioxide and water to make food for plants).

Its basic structure is a heme-like porphyrin ring with a central atom of magnesium rather than iron.

What is the difference between chlorophyll and chlorophyllin acid?

Chlorophyll supplements are partly made from seaweed (chlorella), and because natural chlorophyll is less stable, degrades easily, and is relatively expensive, most over-the-counter chlorophyll supplements are actually the main component of chlorophyllin.

Chlorophyllin is a semi-synthetic derivative of chlorophyll (usually extracted from the more readily available fescue and alfalfa plants) combined with sodium copper salt, also known as sodium copper chlorophyll, which is water-soluble and does not require fat to assist absorption.

Chlorophyll is often used as a food additive or health supplement, and is thought to have anti-cancer, anti-diabetes, anti-lipid, anti-mutagenesis, anti-odor, anti-oxidation, antibacterial, antiviral, detoxification and other effects.

What are the empirical effects of chlorophyll

Chlorophyll is beneficial for allergic rhinitis

Allergic rhinitis is an under-recognized inflammation of the nasal mucosa, defined as at least two nasal symptoms, including a runny nose, blockage, sneezing, and nasal itching.

It is mainly caused by the inhaled allergen reaction mediated by immunoglobulin E (IgE), which is prone to work, learning, sleep problems and reduced outdoor activities in children.

Typical allergens include seasonal pollen and mold, as well as indoor perennial allergens such as dust mites, pets, pests, and some molds.

A randomized, double-blind, placebo-controlled 12-week trial in 66 patients with seasonal allergic rhinitis showed that oral chlorophyll capsules (0.7 mg daily) reduced the need for additional allergy medications.

Chlorophyll may be helpful in improving seasonal allergic rhinitis, but due to the small sample size, more studies are needed to confirm its clinical benefit.

Chlorophyll prevents aflatoxin-associated liver cancer

Aflatoxin is mainly produced by the fungi Aflatoxin, Aspergillus parasiticus and Aspergillus nomus, which are parasitic in A variety of foods such as corn, oilseeds, spices, peanuts, nuts, milk and dried fruits, especially aflatoxin B1 is the most abundant and most toxic member of the family (has been classified as A Class A carcinogen by the World Health Organization).

Among the many risk factors for liver cancer, hepatitis B and C virus infection, aflatoxin exposure, heavy alcohol consumption, and iron overload are the most common.

Once aflatoxin has been ingested, its metabolite AFB1-N7-guanine is considered an important biomarker for determining DNA damage

A randomized, double-blind, placebo-controlled, 4-month study of 180 healthy adults showed that urine AFB1-N7-guanine levels were 55% lower in the chlorophyll group than in the placebo group.

Chlorophyll intake can reduce AFB1-N7-guanine in high-risk aflatoxin-exposed populations, and may have a positive effect on the prevention of liver cancer.

3. Chlorophyll helps control body odor

The chemical complexity of body odor allows it to convey a variety of biological and social information, and in humans and animals, the signals hidden in body odor are thought to aid in mate selection, individual recognition, kinship detection, and sexual differentiation.

While body odor can generate spontaneous personality trait attributions, unpleasant body odor is generally less desirable and is considered a warning sign or indicator of potential health risks, although not necessarily a direct cause of health problems.

A study of 62 elderly nursing home patients showed that taking chlorophyll, in addition to controlling body odor and fecal odor, can also reduce constipation and flatulence.

Other studies have shown that for patients with trimethylaminuria (also known as smelly fish disease, a rare disease in which the body cannot break down trimethylamine), oral chlorophyll can significantly reduce the concentration of trimethylamine in urine.

* Trimethylamine is described as smelling like rotten fish/eggs, garbage, or urine, and when this compound accumulates in the body, it gives off a strong fishy smell in sweat, urine, and breath.

Oral chlorophyll may be positive in improving body odor, but limited by small sample size, more large-scale trials are needed to confirm its clinical benefits.

Chlorophyll improves pimples

Acne is an inflammatory sebaceous gland disease characterized by blackheads, pimples, pustules, inflammatory nodules, epidermal cysts, and pustules. Although it does not affect general health, severe acne can lead to scarring and psychological distress.

Lesions are most common on the face, but the neck, chest, upper back and shoulders can also be affected, with more than 80% of adolescents suffering from pimples, and 3% of men and 12% of women lasting over the age of 25.

A controlled study (4 weeks of 24 acne patients) in which one group received light therapy and the other group received topical application of chlorophyll liposome complex combined with light therapy.

The results showed that compared with the subjects treated with light therapy alone, the acne damage count, severity grade and sebum level in the chlorophyll group were significantly lower.

ChlorophylL-photodynamic therapy is positive for the improvement of acne, especially for subjects that do not respond well to traditional treatment or have contraindications.

Chlorophyll prevents colorectal cancer

Colorectal cancer is the most common malignancy of the gastrointestinal tract, ranking third in men and second in women, respectively. Major risk factors include advanced age, family history, masculinity, lifestyle (smoking, high consumption of red and processed meats, obesity, diabetes, and excessive alcohol consumption).

However, it is also one of the most preventable cancers because it almost always starts in benign tumors, also known as tubular adenomas and serrated polyps, that take many years to evolve into colorectal cancer

Therefore, early detection and removal of precancerous adenomas are essential to prevent malignant transformation of polyps.

A population-based study (120,852 participants followed for 9.3 years) found that increased dietary heme iron intake and decreased chlorophyll intake were associated with an increased risk of colorectal cancer in men.

Conclusions: Higher dietary chlorophyll intake is associated with a lower risk of colorectal cancer

Does chlorophyll have side effects

For most people, chlorophyll is safe when taken orally.

references

1、Efficacy of chlorophyll c2 for seasonal allergic rhinitis: single-center double-blind randomized control trial

2、Chlorophyllin intervention reduces aflatoxin–DNA adducts in individuals at high risk for liver cancer

3、Photodynamic therapy using chlorophyll-a in the treatment of acne vulgaris: a randomized, single-blind, split-face study

4、Heme and chlorophyll intake and risk of colorectal cancer in the Netherlands cohort study

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