리코펜은 인슐린 저항성을 감소시키고 혈관 노화를 역전시킬 수 있습니다.

There are usually two phenomena in the aging process of people, insulin resistance and capillary aging. Both prevent the body’s tissues from getting enough glucose. The result is muscle loss, osteoporosis and other common symptoms of older people, and an increased risk of Alzheimer’s disease. In 2021, a team at Wuhan University found that lycopene supplements , the pigment that gives tomatoes and watermelons their red color, reduced insulin resistance and increased capillary density in aging rats. The study was published in the Journal of Nutritional Chemistry.

To induce aging symptoms in young rats, the researchers injected 300mg/kg of D-galactose (an aging inducer commonly used in biological experiments) daily for eight weeks, along with an additional 100mg/kg of lycopene tablets daily. This dose translates to the human body equivalent to about lycopene 10 mg,now lycopene 20 mg ,lycopene 40 mg, lycopene 50mg,450mg of best lycopene supplement per day, relying solely on diet to obtain, you need to eat 10kg of tomatoes to reach 2.

After eight weeks of treatment, the researchers gave the rats a glucose tolerance test. They were given 2g/kg of glucose orally after fasting for 16 hours, and their blood sugar status was continuously monitored for 120 minutes. At the same time, the researchers also prepared a reference group of naturally aged 36-month-old rats and younger 4-week-old rats, which underwent the same glucose tolerance test.

The results showed that the aging rats injected with 리코펜 significantly reduced insulin resistance, not only in their lower fasting blood glucose concentration, but also glucose tolerance than other aging rats, similar to that of young rats.

In addition, lycopene lycomato prostate injection reversed the aging of capillaries in aging rats, and their limb blood flow was significantly improved, similar to that of young rats.

Further studies found that the effect of tomato lycopene on increasing capillary density was associated with a reduction in insulin resistance. Now Lycopene capsules treated rats not only increased muscle capillary density, but also significantly increased the expression levels of p-Akt, Glut4 and VEGF proteins, which are key factors in the insulin signaling pathway PI3K-AKt-GLUT4.

Overall, this study confirmed the role of lycopene in reducing insulin resistance and reversing vascular aging in rats, but its deficiency is that the experiment was only conducted in muscle tissue, while the liver, heart and brain, which also have a high demand for blood flow, remain to be studied. When the role of lactolycopene on these tissues is clarified in the future, its anti-aging effect can be better used by people.

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참조:

1. 1. Li, J., Zhang, Y., Zeng, X., Cheng, Y., Tang, L., Hong, D., & Yang, X. (2022). Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1. The Journal of nutritional biochemistry, 99, 108862. https://doi.org/10.1016/j.jnutbio.2021.108862

2. 2. Fan Fangfang, WEI Ningguo, ZOU Li et al. Lycopene extraction process optimization and application [J]. Journal of agricultural products processing, 2022, No. 559 (17) : 35-38 + 43. DOI: 10.16693 / j.carol carroll nki. 1671-9646 (X) 2022.09.009.

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