ミルクアザミ抽出物シリマリン
Silymarin (Silymarin) is a natural flavonoid lignan-like compound that is extracted from the dried fruit of milk thistle, a plant in the asteraceae family. Its main components are silybin, isosilybin, silydianin and silychristin.
Properties: Brown powder
CAS Number: 65666-07-1
Molecular formula: C25H22O10
Molecular weight: 482.436
Detection method: HPLC
Nature
Silymarin is insoluble in water, soluble in acetone, ethyl acetate, methanol ethanol, slightly soluble in chloroform.
Pharmacological action
Remove reactive oxygen species
Eliminate reactive oxygen species directly, combat lipid peroxidation, and maintain the fluidity of cell membranes. 2, liver protection water
Silymarin has a protective effect against liver damage caused by carbon tetrachloride, galactosamines, alcohols and other hepatotoxins.
抗腫瘍効果
Various reactive oxygen species can oxidize guanine to form 8 – antelope guanine, causing DNA damage, and then causing tumors, the application of antioxidants, especially free radical scavenger can prevent the occurrence of this process.
Anti-cardiovascular disease effect
ksoottva et al. studied the oxidation effect of milk thistle extract on high cholesterol and low density lipoprotein in mice. Mice fed with polyunsaturated fatty acid and a small amount of saturated fatty acid containing milk thistle extract showed a significant decrease in serum cholesterol content in the former compared with mice fed with polyunsaturated fatty acid and a small amount of saturated fatty acid. VLDL hair decreased and HDL-C increased, indicating that silymarin improved the anti-LDL ability.
Protective effect of cerebral ischemic injury
Feng Quan et al. investigated the mechanism of the protective effect of silymarin on ischemic brain injury by creating a rat model of global cerebral ischemia with four-vessel blockade method. By observing the expression levels of nitric oxide and nitric oxide synthase in brain homogenate, it was shown that silymarin significantly reduced the content of NO and NOS in the cerebral tissue of ischemic rats and significantly reduced the infarct size. Therefore, it is concluded that silymarin can improve the antioxidant capacity of the body and has a significant protective effect on cerebral ischemia injury.
This product can inhibit lipoxygenase and peroxidase. Clinically, it is used for the treatment of liver poisoning, liver dysfunction, anti-radiation and hypolipidemia.
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