美白分野におけるグルタチオン
The importance of whitening is self-evident, as long as the skin is white, the whole person feels more spiritual, more beautiful, in addition to aesthetic factors, white skin is also a sign of healthy skin. Glutathione is one of the most amazing whitening artifacts.
glutathione (r-glutamyl cysteingl +glycine (GSH)) is a tripeptide containing gamma-amide bonds and thiol groups, composed of glutamic acid, cysteine, and glycine, which is present in almost every cell of the body.
グルタチオン and reduced glutathione helps maintain normal immune system function and has antioxidant, integrative and detoxifying effects. The sulfhydryl group on cysteine is its active group (often abbreviated as G-SH), which is easy to combine with some drugs, toxins, etc., so that it has an integrated detoxification effect. Glutathione can not only be used as medicine, but also as the base material of functional food, which is widely used in functional food such as delaying aging, enhancing immunity and anti-tumor.
グルタチオン and l glutathione can be reduced (G-SH) and oxidized (G-S-S-G) in two forms, and the reduced glutathione is the majority under physiological conditions. Glutathione reductase can catalyze tautosis between the two types, and the coenzyme of this enzyme can also provide NADPH for pentose phosphate bypass metabolism.
How does Chinese Medicine understand whitening
From the perspective of traditional Chinese medicine, not white is often poor health, zang-fu qi and blood disorders, in a state of sub-health performance. Chinese medicine believes that the most easy to affect the skin color, when the liver, spleen, kidney three viscera. In the theory of traditional Chinese medicine, it is believed that the skin color of a person is nourished by the internal zang-fu organs. In the theory of viscera, it is mentioned that it is necessary to nourish in the inside and beauty in the outside. If the viscera is dysfunctional, the qi and blood are not smooth, the essence is insufficient, and the Yin and Yang are disordered, the skin color is easy to be dull, and the skin is easy to produce color spots and puffiness and relaxation. If people are often in a busy, stressful, tense and poor mood, irritable state, there will be liver qi stagnation, traditional Chinese medicine believes that the liver is the main dredge and hill relief, the function is to relieve the body qi, blood and body fluid, liver qi stagnation will produce qi and blood disorder and stasis, the skin will be waxen and dark, this is the so-called liver qi stagnation.
The reason why the spleen affects skin color is that traditional Chinese medicine regards the spleen as the source of Qi and blood biochemistry. The so-called spleen in traditional Chinese medicine is not the spleen of Western medicine, but the whole digestive system. Therefore, the spleen dominates the middle state, which means that the spleen mainly absorbs nutrients and nourifies other viscera in the five viscera. If eating disorders and restlessness affect digestive function, the phenomenon of spleen deficiency and dampness will occur.
As for the kidney in Chinese medicine is believed to be the kidney water, that is, the master of the body body fluid balance, if overwork will make the water deficit fire prosperous, empty fire rise and stagnation does not disperse, the skin rough dark; In addition, Chinese medicine believes that the lung is the main skin, because the lung is the master of Qi, the kidney is the root of qi, the kidney deficiency or the kidney water shortage will affect the lung function, the skin color will become worse and not bright white. Therefore, nourishing zang-fu organs, protecting liver and replenishing blood is the foundation of whitening.
In the face of many whitening products, whether it is advertised as detoxifying, inhibiting peroxy reaction, removing free radicals, removing melanin, etc., the most important ingredient is glutathione. Let’s meet this amazing thing that looks like a Japanese name. She is also the most important ingredient in whitening products.
glutathione l glutathione (glutathione for short) is a tripeptide composed of glutamic acid, cysteine and glycine, containing sulfhydryl, which has antioxidant and integrated detoxification effects. Glutathione plays an important role in the biochemical defense system in the human body, and has many physiological functions. Its main physiological role is to remove free radicals in the human body, as an important antioxidant in the body, to protect many proteins and enzymes and other molecules in sulfhydryl.
The structure of GSH glutathione reduced 250 mg contains an active sulfhydryl -SH, which is easily dehydrogenated by oxidation, and this specific structure makes it the main free radical scavenger in the body. For example, when a small amount of H2O2 is produced in the cell, GSH reduces H2O2 to H2O under the action of glutathione peroxidase, and itself is oxidized to GSSG, which receives H to be reduced to GSH glutathione reduced 500 under the action of glutathione reductase present in the liver and red blood cells, so that the free radical scavenging reaction in the body can be continued. Glutathione can not only eliminate free radicals in the human body, but also improve human immunity. Glutathione is healthy and anti-aging, and has a greater effect on the cells that slow down in older people than in younger ones.
healthvit l glutathione can also protect hemoglobin from hydrogen peroxide oxidation, free radicals and other oxidation, so that it can continue to perform normal oxygen transport capacity. Part of the hemoglobin in the red blood cells under the action of oxidizing agents such as hydrogen peroxide, in which the bivalent iron is oxidized to trivalent iron, so that the hemoglobin is transformed into methemoglobin, thus losing the oxygen carrying capacity. Reduced glutathione can not only directly combine with oxidizing agents such as hydrogen peroxide to form water and oxidized glutathione, but also reduce methemoglobin to hemoglobin.
グルタチオン is abundant in human red blood cells, which is of great significance to protect the sulfhydryl group of proteins on the red blood cell membrane in a reduced state and prevent hemolysis. Glutathione protects the -SH group in the enzyme molecule, which is conducive to the play of the enzyme activity, and can restore the activity function of the -SH group in the enzyme molecule that has been destroyed, so that the enzyme can resume the activity. Glutathione can also inhibit the fatty liver caused by alcohol damage to the liver (love drinking, sallow face friends, you still use early, you may be alcoholic liver).
Glutathione has a strong protective effect on the symptoms of leukopenia caused by radiation and radiopharmaceutics. Glutathione can be combined with toxic compounds, heavy metal ions or carcinogens that enter the human body, and promote their excretion from the body, playing a role of neutralization and detoxification. Glutathione has a broad spectrum detoxification effect, which can not only be used as drugs, but also as the base material of functional foods, and is widely used in functional foods such as delaying aging, enhancing immunity, and anti-tumor. Glutathione drugs are widely used in clinical, in addition to the use of its sulfhydryl group to chelate heavy metals, fluoride, mustard gas and other toxins poisoning, but also used in hepatitis, hemolytic diseases and keratitis, cataracts and retinal diseases, as a treatment or adjuvant therapy drugs.
The latest research also shows that GSH can correct the imbalance of acetylcholine and cholinesterase, play an anti-allergic role, prevent skin aging and pigmentation, reduce the formation of melanin, improve skin antioxidant capacity and make skin shine, in addition, GSH in the treatment of keratopathy and improve sexual function also has a good role.
In addition, vitamin C is an important antioxidant in the body. Because vitamin C can be reversibly hydrogenated or dehydrogenated, vitamin C plays an important role in many REDOX reactions in the body. For example, the active group of many enzymes is sulfhydryl (-SH), and vitamin C can maintain -SH in a reducing state and maintain enzyme activity; Vitamin C can transform oxidized glutathione into reduced glutathione (GSH) and reduce hydrogen peroxide (H2O2) produced by body metabolism. Vitamin C also protects vitamins A, E and certain B vitamins from oxidation.
Therefore, the use of glutathione, when combined with vitamin C, can improve its efficacy. To this end, glutathione can restore a woman’s pearl-like white skin, and can fade stubborn spots, remove wrinkles, increase skin elasticity, shrink pores, fade pigment, whole body whitening has an excellent effect.
In real life, as we grow older, unhealthy lifestyle, the deterioration of the ecological environment, the level of glutathione in the human body will decline, which will bring harm to the body, especially people become more and more old and yellow, wrinkled face, old age.
Whitening recommendation: Many fruits contain glutathione, such as tomatoes (commonly known as tomatoes), cherries, cherry tomatoes (commonly known as small tomatoes) and so on. Therefore, eating more fruit in daily life is beneficial to delay aging and prolong life.
Refer to published literature
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