ジェニポシド 30%

Chemical properties of gardeniin

Soluble in water, soluble in ethanol, insoluble in petroleum ether.

Pharmacological effect of gardenin

Geniposide has inhibitory effect on hemolytic streptococcus and skin fungi. It has antipyretic, analgesic, sedative, antihypertensive and hemostatic effects. Purging fire and eliminating boredom, clearing heat and dampness, cooling blood and detoxification, detumescence and pain relief. Symptoms include fever upset, manic disturbance, high fever irritability, dizziness and delirium, jaundice, red urine, heat and astringent pain, blood and heat epistaxis, eye red swelling pain, fire and poison sore; External treatment of contusion pain.

Application of gardenin

Gardenia jasminoides Ellis is derived from the dried ripe fruit of the Rubiaceae plant Gardenia Jasminoides Ellis. There are more than 40 kinds of physiological active substances in gardenia gardenia, among which the effective components of Chinese medicine recognized at home and abroad are iridoid substances. The iridoid substances contained in gardenia include geniposide, geniposide, hydroxyisogeniposide and geniposide, among which geniposide and geniposide are the highest active ingredients. Gardenin is also an intermediate for the production of gardenia blue, gardenia red and gardenia purple, and an effective monomer for pharmaceutical production. Therefore, the separation, purification, crystallization and content determination of jasminoside have become the key technologies for further development of Jasminoside. The separation of geniposide can be carried out simultaneously with the separation of α-crocin. The more mature method is the adsorption and desorption technology of macroporous resin. The selected resins are mostly weak and non-polar, such as HP20, XAD22, HPD2100, X25, NKA and so on. The main purification methods reported in the literature are: lead salt precipitation, activated carbon impurity removal, silica gel adsorption, etc. The preliminary conclusion from the comparative study is that the above methods are acceptable as research, but can not be used for industrial production. The main problems are: the process is complicated, the material consumption is too large, the yield is low, and a lot of toxic and harmful reagents are used, such as ether, chloroform, methanol, acetone, lead salt and so on. Does not meet the food and drug production standards. The purification of geniposide can be achieved by using column chromatography. The selection of safe, non-toxic, suitable fixed phase and mobile phase, under certain adsorption capacity, temperature, pH, flow rate, flow rate and other conditions, can effectively purify the content of gardenoside from 50% to 95%, creating the necessary conditions for the crystallization of gardenoside. The determination methods of the content of gardenoside include thin layer ultraviolet method, thin layer scanning method, high performance liquid chromatography, etc. The accuracy of thin layer ultraviolet method and thin layer scanning method is not high. High performance liquid chromatography is an accurate and rapid quantitative determination method of gardenoside, which is the establishment of its quality standard.

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