レスベラトロールを多く含む食品と飲料

レスベラトロール

レスベラトロール is a bioactive substance known to be found in grapes, red wine, and grape juice, but it’s also found in blueberries, cranberries, peanuts, and even pistachios. In nature, resveratrol is a natural fungicide that fights fungi that destroy plants, so it is a biologically active substance that is a primary component of a plant’s health defense system.

When people consume resveratrol, different types of human cells are stimulated and behavior is also affected. For example, resveratrol activates cardiac stem cells, which normally lie dormant in your heart but are able to regenerate heart tissue in response to stress. Scientists from Soochow University, Kunshan Third People’s Hospital and Nanjing Medical University studied the effects of resveratrol on cardiac stem cells in mice. They gave resveratrol to healthy normal mice every day for a week and found that even in the absence of disease, resveratrol increased the number of heart stem cells in heart tissue by 0.7-fold.

In mice that had suffered a heart attack, the researchers injected 1 million cardiac stem cells to see if they could save the heart. Animals given resveratrol along with the stem cells increased the number of blood vessels in their hearts and almost doubled the survival rate of cardiac stem cells.

The challenge with actual intake of resveratrol is that it is found in too little in red wine and most foods, so people would need to consume a lot of wine to match the amount used in most studies. Because of this, resveratrol may be one of the few exceptions, where bioactive substances may be better obtained from concentrated supplements than from real food

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Foods rich in zeaxanthin

Zeaxanthin is a bioactive substance belonging to carotenoid. It is a pigment that gives corn and saffron their orange-yellow color, but it is also common in leafy greens such as kale, mustard greens, spinach, watercress, carsuras, and bracken. Zeaxanthin is also found in high levels in goji berries, a red, flat, oval berry used in Asian herbal teas, soups and stir-fries. This bioactive substance is very important for the health of the eyes. After eating foods containing zeaxanthin, zeaxanthin accumulates in the retina, the layer at the back of the eye that senses light and transmits it to the brain. Clinical studies have shown that eating zeaxanthin can help protect the eyes from the blinding effects of age-related macular degeneration.

Scientists from Jinan University in Guangzhou and Shenzhen Third People’s Hospital in China studied the effects of zeaxanthin on stem cells. They used liposuction to extract stem cells from human fat and exposed them to zeaxanthin. These stem cells survived better than those not exposed to zeaxanthin and showed fewer signs of inflammation. The scientists then tested whether zeaxanthin could help stem cells save organs damaged by disease. They injected 2 million mesenchymal stem cells, derived from human fat tissue, into mice with failing livers, so they could regenerate mouse livers. Some of the mice were injected with stem cells that had previously been exposed to zeaxanthin, while the rest were injected with untreated stem cells. After seven days, common stem cell therapy reduced liver damage by about half. However, in mice injected with stem cells treated with zeaxanthin, the stem cells reduced liver damage by 75 percent over the same period.

The results of this study suggest that eating foods containing zeaxanthin may contribute to the performance of our stem cells in organ regeneration.

Foods rich in chlorogenic acid

Chlorogenic acid is another powerful bioactive substance found in abundance in coffee, but also in black tea, blueberries, peaches, fresh plums and prunes, eggplants, and even bamboo shoots. It has anti-inflammatory, antiangiogenic and antihypertensive effects. Its benefits also include the protection of stem cells. Researchers at Nanchang University in China studied how chlorogenic acid affects the survival of mesenchymal stem cells, which are involved in organ healing and regeneration. They found that when the stem cells were exposed to chlorogenic acid, they were more resistant to stress and doubled their survival rate, increasing their ability to participate in keeping the body’s organs healthy.

Black raspberry

The dark color and sour taste of black raspberry indicates that it contains many potent bioactive substances such as ellagic acid, ellagitannin, anthocyanins and quercetin. In fact, a dietary supplement made from black raspberries has been clinically shown to benefit colon cancer patients and people with pre-diabetes. Ellagic acid in black raspberries activates stem cells. Researchers at Korea University Annan Hospital in Seoul studied the effects of the berry on 51 patients with metabolic syndrome. This is a collection of dangerous health conditions such as obesity, high blood sugar, high blood pressure, high triglycerides and low HDL (good cholesterol), and anyone with these conditions is at high risk for cardiovascular disease. The researchers drew their blood at the start of the study and measured the number of their circulating stem cells. The researchers then gave the patients either black raspberry powder or a placebo every day for 12 weeks.

They found that those who ate black raspberry powder had a 30 percent increase in circulating endothelial progenitor cells, while those who ate a placebo actually had a 35 percent decrease in stem cell levels due to metabolic syndrome. When the researchers measured the hardness of blood vessels in people who ate black raspberry powder, they found that these people’s blood vessel hardness decreased over 12 weeks, reflecting their healthier blood vessels and the benefits of more circulating stem cells.

Chinese celery

Chinese celery, a common vegetable in Asia, has a thinner stem and a stronger flavor than Western celery. You may have eaten it in a Chinese stir-fry dish, as it is usually on the menu of authentic Chinese restaurants. The leaves, stems and seeds of Chinese celery are edible and contain a variety of bioactive substances that promote health, one of which is 3-n-butylphthalein (NBP). 3-n-butylphthalein is important because it was approved by Chinese regulators in 2002 as a drug for doctors to use as a neuroprotective treatment for stroke patients. 3-n-butylphthalein, also found in supplements containing celery seed extract, may improve brain circulation, reduce brain inflammation, enable nerve growth, and reduce damage to the brain from stroke.

Researchers at Soochow University in China studied how 3-n-butylphthalein could help stroke patients recover. They recruited 170 people who had suffered an acute ischemic stroke, a condition in which a blood clot interrupts blood flow and triggers the death of part of the brain. In the trial, some patients received 3-n-butylphthalein orally, while others received only standard treatment. Blood was drawn seven, 14 and 30 days after treatment. In all patients, the number of stem cells in the blood increased immediately after a stroke, which is an expected response to a person’s regenerative health defense system, but in patients who received only standard treatment, stem cell levels decreased after the seventh day. In contrast, in patients treated with 3-n-butylphthalein, their circulating stem cells steadily increased. By day 30, circulating stem cell levels were 75 percent higher in patients treated with 3-n-butylphthalein than in patients treated with standard therapy alone. CT scans of the brain showed that people who took 3-n-butylphthalein also had improved blood flow in areas of the wind, which can be explained by an increase in the number of stem cells called to the damaged part of the brain.

While these results come from a drug form of 3-n-butylphthalein, it suggests that a bioactive substance contained in Chinese celery has properties that activate stem cells, which may help with organ healing and regeneration after a major illness such as stroke.

mango

Mango is a stone fruit with very sweet, orange-coloured flesh that can be eaten raw, cooked, dried or pickled, or cooked with other ingredients, and is commonly used in Southeast Asian and Latin American dishes. Although mango contains a variety of bioactive carotenoids that give the flesh an orange color, it also contains a unique bioactive substance, mango side, which has anti-tumor, anti-diabetic and regenerative properties. In laboratory animals, mango has been shown to improve blood sugar control by regenerating islet beta cells in the pancreas, which produce insulin.

Scientists from Sichuan Academy of Medical Sciences and Sichuan People’s Hospital, Sichuan University and Leshan People’s Hospital in southwest China found that mango increased the number of islet beta cells in the pancreas of mice by 67 percent, and also activated genes for regeneration and insulin production, thereby increasing the amount of insulin secreted by mice. Other scientists have shown that mango can promote bone regeneration. These studies were conducted by injection of mangiferin, so we cannot directly translate the dose to the consumption of mangiferin, but the results suggest that mangiferin has significant biological activity.

Red wine

Drinking red wine in moderation is beneficial to health. Researchers at the Taipei Veterans General Hospital in China studied stem cells from 80 healthy people in their 30s. They drank either red wine (half a glass), beer (one can), vodka (one small glass) or water every day for three weeks. During the study period, they were prohibited from drinking tea, grape juice, or all other alcoholic beverages in addition to the beverages specified above. At the start of the study, blood pressure, stem cell levels and other physical parameters were similar for all of them.

After 3 weeks, blood tests showed that the red wine drinkers had doubled the levels of endothelial progenitor cells circulating in their blood. Participants who drank beer, vodka or water did not enjoy the same benefits. When these stem cells were exposed to red wine or resveratrol, they had a greater ability to migrate, form blood vessels and survive. In addition, those who drank red wine had a 35 percent increase in the ability of their blood vessels to dilate, a sign of vascular health. Red wine drinkers also had 50% more of the powerful signal nitric oxide in their blood, one of the body’s most basic signals for good health. Nitric oxide not only helps blood vessels dilate, but also stimulates angiogenesis, promotes healing, and sends signals to activate stem cells. When it comes to red wine, more is not always better. The researchers reported that this benefit was seen with 1-2 glasses of wine per day, but the more wine was consumed, the smaller the benefit. It’s important to know that high levels of alcohol can actually damage stem cells and interfere with their ability to regenerate organs. So, as with most foods in your diet, moderation is key. Researchers at the Mario Negri Institute of Pharmacology in Italy analyzed 13 clinical studies on red wine and its effects on cardiovascular disease, a comprehensive study involving 209,418 people. After their analysis, they concluded that drinking red wine was associated with a 32 percent lower overall risk of atherosclerosis.

Green tea

Green tea has many well-studied health benefits, one of which is activating the regenerative system. This has been studied in smokers. Chemically, smoking burns the lining of blood vessels, which increases the risk of atherosclerosis and cardiovascular disease. Smoking also damages stem cells, reducing the number of circulating stem cells. People who smoke have 60 percent fewer stem cells in their blood than non-smokers, which is another reason not to advocate smoking.

Researchers from Chonnam National University Hospital in South Korea and Nagoya University Graduate School of Medicine in Japan studied the effects of drinking green tea on stem cells in smokers. They recruited 20 young people in their late 30s who had smoked for six years and had them drink four cups of green tea (56 cups in total) every day for two weeks. The researchers drew the subjects’ blood at the beginning and end of the study to count the number of circulating endothelial progenitor cells in existence. The results showed that drinking green tea increased the number of circulating stem cells by 43 percent over two weeks.

During the study period, green tea also improved the health of the smokers’ blood vessels, with a 29 percent increase in their vasodilation response. In the lab, scientists have found that green tea and its catechins stimulate the regeneration of the brain, muscles, bones and nerves, and can promote wound healing. 42 Green tea is good for the regenerative system of the whole body, which is another reason to recommend drinking green tea.

Black tea

It was once thought that black tea had no health benefits because it was fermented and contained fewer polyphenols than green tea. But researchers at the University of L ‘Aquila in Italy have shown that black tea can actually mobilize stem cells. To study this effect, they recruited 19 people in their 50s who had recently been diagnosed with mild to moderate high blood pressure but had not yet received any medication. The subjects had no other medical conditions and were not taking any medications. They were given either a cup of black tea or a placebo drink to drink twice a day for a week and told not to add any milk, sugar or other additives to their tea. The researchers measured the number of circulating endothelial cells in their blood. After one week, drinking black tea increased circulating endothelial progenitor cells by 56%. Drinking two cups of black tea a day also improves the health of the vascular system, which can be seen in the increased ability of blood vessels to dilate in those who drink black tea. To see if black tea could protect blood circulation from dietary fat, the researchers had subjects consume whipped cream, which is high in fat, and then drink black tea. Eating whipped cream has a surprisingly rapid negative effect on blood flow. In fact, within two hours of eating whipped cream, blood vessel dilation decreased by 15 percent. However, drinking black tea can protect the tea drinker’s blood flow from this effect and maintain the ability of blood vessels to dilate.

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