Resveratrol and health
Resveratrol is a type of non-flavonoid polyphenol compound, mainly found in grapes, hellebore, knotweed and other plants. Its structure is similar to synthetic diethylstilbestrol. It is considered a phytoestrogen and can prevent estrogen Serious side effects that occur with alternative treatments.
Studies have found that resveratrol has anti-platelet aggregation, antioxidant, anti-inflammatory, anti-aging and tumor prevention effects.
Resveratrol antioxidant
Resveratrol is a natural antioxidant that mainly exerts antioxidant effects by scavenging free radicals, inhibiting the generation of free radicals and lipid peroxidation, and regulating the activity of antioxidant-related enzymes and gene expression.
This is also one of the important mechanisms by which resveratrol prevents and intervenes in certain diseases, such as anti-tumor, cardiovascular protection, prevention of tissue and organ damage, liver protection, anti-shock, etc.
Resveratrol cardiovascular protective effect
In cardiovascular diseases, resveratrol can be anti-inflammatory, antioxidant, regulate the expression of various factors, affect atherosclerosis, hypertension, ischemic heart disease, heart failure and other cardiovascular disease processes, and play a protective role. heart function, resveratrol may be a candidate intervention for the prevention and treatment of cardiovascular disease.
Resveratrol resveratrol and type 2 diabetes
Resveratrol has various physiological effects such as lowering blood sugar, improving insulin resistance, regulating abnormal lipid metabolism, reducing inflammatory factors, anti-oxidation, inhibiting platelet aggregation, relaxing blood vessels, and increasing NO production. However, most of the current research results are derived from in vitro Experiments or animal experiments still need to be studied and confirmed by human clinical experiments.
Resveratrol neuroprotective effect
Studies have shown that resveratrol can significantly inhibit the production of DNA during oxidative damage to liver microsomes, brain mitochondria and synaptosomes, and is very effective in preventing and treating viral hepatitis, Parkinson’s disease, Alzheimer’s disease and other diseases. effect.
Studies have found that resveratrol can label kinases and nerve cells, and has good preventive and therapeutic effects on degenerative diseases in the elderly, such as Parkinson’s disease, dementia, rheumatic diseases, etc.
Resveratrol inhibits the release of the neurotoxic factor NO and exerts a protective effect on neurons by reducing the phosphorylated expression of p38 and ERK in LPS-activated microglia and increasing the expression of degraded ikBa protein and iNOS.
Resveratrol resveratrol and weight loss
Resveratrol, alone or in combination with other natural compounds, can act on adipocytes through various mechanisms, reduce adipocyte activity, induce adipocyte apoptosis and promote adipocyte decomposition. It has a certain effect on weight loss, but it is relatively High doses may cause toxic side effects.
The simultaneous use of multiple plant compounds can not only reduce the dosage of each compound and avoid potential toxic side effects, but can also affect multiple signaling pathways such as adipocyte production, apoptosis, and decomposition at the same time. The synergistic effect of these phytochemicals can make medications safer and more effective.
Resveratrol dosage Instructions
In the human safety studies of resveratrol, the highest single oral dose was 5g/70 (kg·bw), and the highest repeated intake dose was 0.9g/d. In these studies, the adverse reactions that occurred were average. Mild, some studies suggest that side effects are not clearly related to the dose taken. Due to lack of information, my country has not yet formulated SPL and UL.
Resveratrol main food sources
The content of resveratrol is relatively high in plants or fruits such as grapes, mulberries, pineapples, peanuts, cocoa powder, winter bamboo shoots, white cauliflower, and wild rice.
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参考文献
[1] Chinese Nutrition Society. Reference intake of dietary nutrients for Chinese residents. Beijing: Science Press, 2014. [2]Gu J , Hu W , Zhang DD . Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity[J]. Journal of Cellular & Molecular Medicine, 2015, 19(10):2324-2328.[3]Catterall , F. , et al. “Differential modulation of the genotoxicity of food carcinogens by naturally occurring monomeric and dimeric polyphenolics.” Environmental and Molecular Mutagenesis 35.2(2000):86-98.[4] Rayalam S, MA Della‐Fera, Baile CA . Synergism between resveratrol and other phytochemicals: Implications for obesity and osteoporosis[J]. Molecular Nutrition & Food Research, 2011, 55(8).
