Magnolia officinalis-Extrakt Magnolienphenol insgesamt
Total phenol from Magnoliaceae magnolia bark (Magnoliaceae) plant magnolia officinalis MagnoliaofficinalisRehd. EtWils. And concave Ye Houpiao MagnoliaofficinalisRehdChemicalbook. EtWils. Var. BilobaRehd. EtWils. An active substance extracted from dry bark, branch bark and root bark. It has antibacterial, anti-inflammatory, anti-tumor, anti-endomycin, muscle relaxation and relief of acute inflammatory pain.
The total phenol of magnolia officinalis 50% 98%
Character: White or brown powder
CAS number: 528-43-8
Molecular formula: C18H18O2
Molecular weight: 266.33
Nachweismethode: HPLC
Magnolia officinalis extract nature
Soluble in benzene, ether, chloroform, acetone and common organic solvents, insoluble in water. Derived from Magnolia officinalis Rehd.et Wils, a deciduous tree from Magnoliaceae.
Magnolia officinalis extract preparation
A method for preparing high-purity magnolia officinalis total phenol from magnolia officinalis bark comprises the following process steps:
1) Dry the bark of magnolia officinalis, crush the bark and set aside;
2) The crushed bark of magnolia officinalis was extracted to obtain the oil extract, namely the crude extract of total phenol of magnolia officinalis A, and set aside;
3) Weigh the silica gel with the weight of 20%~50% of the crude extract of Magnolia officinalis total phenol A, stir it well with the crude extract of magnolia officinalis total phenol A, then add the silica gel with the weight ratio of 3~6 times of n-hexane, heat it to 60~80℃ for extraction, filter the n-hexane extract, and repeat the extraction for 1~3 times with the filter residue, and combine the n-hexane extract to obtain n-hexane extract B. Standby;
4) The n-hexane extract solution B was concentrated in vacuum, crystallized in cold storage, and the crystallization temperature was controlled by 2℃-5℃. Then the magnolia officinalis n-hexane was crystallized and filtered to obtain the white magnolia officinalis total phenol crystal C;
5) The magnolia magnolia total phenol crystal C was added with petroleum ether at a boiling point of 60~90℃, the weight ratio of petroleum ether and magnolia magnolia total phenol crystal C was 10~30 times, the water bath was heated to a temperature of 60~90℃, the petroleum ether was kept slightly boiling in the round bottom flask, the total phenol crystal C was completely dissolved, the petroleum ether dissolved supernatant was poured out, and the petroleum ether dissolved liquid was cold crystallizing. The crystallization temperature of magnolia officinalis was controlled at 2℃-5℃. After the crystallization, the crystal D of Magnolia officinalis was extracted and the fine magnolia officinalis total phenol was obtained.
Magnolia officinalis extract Pharmacological effect
Total magnolia officinalis has obvious and lasting pharmacological effects of central muscle relaxation, central nervous inhibition, anti-inflammatory, antibacterial, disease resistance to pathogenic microorganisms, anti-ulcer, antioxidant, anti-tumor, inhibition of morphine withdrawal, inhibition of platelet aggregation, etc. Total magnolia officinalis is used in the treatment of acute enteritis. Bacterial or amoebic dysentery. Chronic gastritis, etc. Among them, in terms of antibacterial activity, total phenol of Magnolia officinalis showed significant antibacterial activity against Gram-positive bacteria, acid-resistant bacteria, filamentous fungi, more significant antibacterial effect on Streptococcus mutans, and the strongest inhibitory effect on staphylococcus. Clinically, it is mainly used to eliminate chest and abdominal congestion, calm central nervous system, athletes muscle relaxation, anti-fungal, anti-ulcer and other drugs. In dogs and rabbits, it can reduce the bleeding rate and bleeding time, and stimulate the uterus.
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