Baicalin, Auszug aus Scutellaria baicalensis
Baicalin is a kind of flavonoid compound extracted from the root of scutellaria baicalensis. It is a light yellow powder with bitter taste at room temperature. Insoluble in methanol, ethanol, acetone, slightly soluble in chloroform and nitrobenzene, almost insoluble in water, soluble in hot acetic acid. When ferric chloride appears green, when lead acetate produces orange precipitate. Soluble in alkali and ammonia, it is yellow at first, and soon becomes black brown. It has significant biological activities, such as antibacterial, diuretic, anti-inflammatory, cholesterol-lowering, anti-thrombosis, relieving asthma, purgative fire and detoxification, antichemicalbook blood, antifetal, anti-allergic reaction and spasmolytic effect. It is also a specific inhibitor of mammalian liver sialoenzyme, has the effect of regulating some diseases, and has a strong physiological effect of anticancer reaction. It is mainly used for the treatment of dampness, heat, chest depression and vomiting, dampness and heat filling, diarrhea and jaundice, lung heat cough, high heat and thirst, blood heat vomiting, carbuncle swollen sore poison, restless fetus. In addition, baicalin can also absorb ultraviolet rays, remove oxygen free radicals and inhibit the production of melanin, which is a good functional cosmetic
Alias: Begalin; baicalin
Source: Extracted from dried root of Scutellaria baicalensis Georgi.
Properties: light yellow powder
CAS Number: 21967-41-9
Molecular formula: C21H18O11
Molecular weight: 446.37
Wirkung
Anti-inflammation and anti-allergy
It can relieve allergic constriction of isolated trachea and asthma of whole animal, and has synergistic effect with ephedrine. It has weak antihistamine effect. When adding antigen to guinea pig isolated perfusion solution, it can reduce the release of histamine and SRS-A, which is stronger than rutin. It can inhibit the passive systemic allergy (PSA), passive skin allergy (PCA) and skin reaction caused by histamine. It can inhibit allergic edema and inflammation, reduce the permeability of ear capillaries, and prevent pulmonary hemorrhage caused by low pressure.
Antibakteriell
As one of the antibacterial ingredients of scutellaria baicalensis, eye drops containing 3% of this product are clinically used for the treatment of trachoma, and the efficacy is similar to rifampicin, a better drug for the treatment of trachoma.
Diuresis
It has diuretic effect on rabbits.
Choleretic
It can increase the bile excretion of dogs and rabbits.
Cure Fever
When administered intraperitoneally or intravenously, it can relieve fever in rabbits heated by vaccine or yeast.
Pressure Reduction
When injected intravenously or intramuscularly or intragastric, anesthetized dogs, cats and rabbits can cause blood pressure reduction.
sedated
Inhibition of spontaneous activity in mice.
andere
It can reduce the death rate of strychnine poisoning in mice, and 10μg can increase its LD50 about 2-5 times. It can reduce the levels of total cholesterol, free cholesterol and triglyceride in the liver of experimental rats.
clinical
It is mainly used to treat hepatitis in China, and has obvious curative effect on acute jaundice type, acute non-jaundice type and chronic hepatitis.
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