Die Kraft von Vitamin E

What is Vitamin E

Vitamin E is a fat-soluble antioxidant, a yellowy, oily substance with eight isomers, which can be divided into tocopherol/tocopherol subtypes and tocotrienol/tocotrienol subtypes (which have an unsaturated side chain).

Each type is further divided into alpha -, beta -, gamma -, or δ- forms, which are defined by the number and position of methyl groups on the naphthol ring, and each varies in terms of stereoisomerization, esterification, and biological activity.

Vitamin E is mainly bound to the hydrophobic interior of cell membranes, protecting cell membranes from damaging oxidation by providing electrons to lipid peroxidation products to clear free radicals, and in the human body, alpha-tocopherol is the most abundant form.

Vitamin E is also known as tocopherol, because it was first found to be related to animal reproduction, if lack of easy to cause infertility and miscarriage, but decades of research shows that vitamin E’s benefits do not end there.

What are the positive effects of vitamin E

1. Beneficial for primary menstrual pain

Menstrual pain is one of the most common gynecological diseases, affecting more than half of menstruating women. Most adolescents experience period pain in the first few years after menarche.

Primary menstrual pain refers to pelvic pain that occurs at the beginning of menstruation without obvious pathological changes. It is a common cause of absenteeism and medical treatment, and seriously affects personal lives and financial aspects.

Severe menstrual cramps are estimated to result in 600 million hours of lost work time and $2 billion in lost productivity each year.

A meta-analysis of the literature (eight randomized controlled trials involving 1002 healthy women with primary dysmenorrhea) indicated that oral vitamin E significantly reduced the mean intensity of primary menstrual pain in the first and second months compared with placebo.

2. Good for male infertility

Infertility affects millions of people of reproductive age worldwide (about 48 million couples and 186 million people), inflicting distress on families and communities, with male factors accounting for about half.

Male infertility can be caused by a variety of factors, including genetics, age, medications, surgical history, exposure to environmental pollutants, genetic abnormalities, and systemic diseases, all of which can affect reproductive ability.

A meta-analysis of the literature (eight randomized controlled trials with 459 male infertility patients) indicated that oral vitamin E significantly increased total sperm count and decreased semen volume (the decrease in semen volume may be the result of the duration of abstinence before and after the trial).

Subgroup analysis showed that the improvement of sperm forward motility was most significant after 6 months of vitamin E treatment.

3. Beneficial nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease is an exclusion diagnosis characterized by the absence of a history of alcohol use and other chronic causes of liver disease (such as viral hepatitis, hemochromatosis, Wilson’s disease, autoimmune hepatitis, drug-induced hepatitis, and hepatitis with chronic endocrine or genetic causes).

Disease progression can range from benign nonalcoholic fatty liver disease to progressive nonalcoholic steatohepatitis with or without fibrosis, cirrhosis, and hepatocellular carcinoma.

NAFLD is the most common cause of chronic liver disease, affecting 15 to 30 percent of the general population, but is more prevalent (about 50 to 90 percent) in people with diabetes, metabolic syndrome, and severe obesity.

A meta-analysis of the literature (15 randomized controlled trials, 1317 patients with NAFLD) indicated that vitamin E (either alone or in combination) had an advantage in improving biochemical outcomes (ALT, AST) in adults and children. It was also beneficial for additional histological improvements (fibrosis and NAFLD activity scores) in adults and metabolic improvements in the pediatric population.

5. Beneficial blood lipid regulation

Hyperlipidemia is a genetic and environmental related multifactorial disease, mainly manifested by plasma dyslipidemia. These include increases in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), as well as decreases in high-density lipoprotein cholesterol (HDL-C).

Hyperlipidemia has been shown to significantly increase the risk of atherosclerosis, stroke, myocardial infarction, and other cardiovascular and cerebrovascular diseases, and is twice as likely to develop cardiovascular and cerebrovascular diseases as people with normal lipids.

A meta-analysis of the literature (10 randomized controlled trials with 613 participants) indicated that vitamin E supplementation did not affect total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels in patients with diabetes.

In addition, subgroup analysis showed that vitamin E supplementation reduced total cholesterol (TC) and increased high density lipoprotein cholesterol (HDL-C) levels only in subjects who continued for 12 weeks.

6. Lower inflammation markers: C-reactive protein

C-reactive protein, an acute phase protein of the pentacyclic protein family, is synthesized by liver cells and is one of the most well-known biomarkers of systemic inflammation, an indicator of a variety of pathological processes including infection, tissue damage and chronic inflammatory diseases.

Elevated levels are considered to be independent and strong predictors of cardiovascular disease and atherosclerotic thrombotic events.

A meta-analysis of 12 randomized controlled trials with 495 participants showed that vitamin E supplementation (in the form of alpha-tocopherol or gamma-tocopherol) reduced serum C-reactive protein levels.

In addition, subgroup analyses showed that participants with baseline CRP water greater than 3mg /l had a more significant decrease in serum CRP levels after vitamin E supplementation than participants with baseline CRP levels of 3mg /l.

Aid weight loss

Obesity is a chronic disease that can lead to a variety of conditions such as diabetes, coronary heart disease and osteoarthritis. There are several factors that can contribute to obesity, including: energy intake exceeding energy requirements, low physical activity, being sedentary, and genetics.

Globally, obesity rates are rising for all ages and genders regardless of geography, race or socioeconomic status, and more than 50 percent of the population will be overweight by 2030, including about 11 percent of Americans who will be severely obese.

A meta-analysis of the literature (24 randomized controlled trials with a total of 1267 participants) found that vitamin E supplementation (interventions ranging from 1 to 24 months and daily doses ranging from 67 to 900 mg) had no significant effects on body weight, body mass index, and waist circumference.

Reduces the risk of senile cataracts

A cataract is an opaque object visible in the lens that causes visual loss when it is located on the visual axis.

Senile cataracts are those that occur after age 50 and are not associated with known congenital, metabolic disorders, drug-induced turbidity, trauma, chemical or radiation factors.

The main mechanism of senile cataract may be related to the following factors, such as: protein breakdown and aggregation, destruction of fiber cell membranes, glutathione deficiency, oxidative damage, calcium elevation, and abnormal migration of lens epithelial cells.

A meta-analysis of 27 studies with 245,531 participants indicated that dietary vitamin E intake, dietary and supplemental vitamin E intake, and higher serum tocopherol levels may be significantly associated with a lower risk of age-related cataract.

Dose-response analysis showed that dietary vitamin E intake to reduce the risk of cataracts starts with an intake of more than 7 mg per day.

Beneficial blood sugar control

Type 2 diabetes is the most common chronic disease in adults, with a global prevalence of 8.3%, or about 330 million people, and the number of people affected is increasing year by year.

Long-term poor blood sugar control is more likely to lead to small and large vascular diseases, such as cardiovascular events, kidney failure, blindness, peripheral neuropathy are associated with.

A meta-analysis of the literature (14 randomized controlled trials with 714 participants) found that, on average, there was insufficient evidence to support that vitamin E supplementation improved HBA1c, fasting glucose, and fasting insulin in patients with type 2 diabetes.

Subgroup analysis found that for subjects with low blood vitamin E concentration and poor blood glucose control, additional supplementation had statistically significant improvements in HBA1c and fasting blood glucose.

Beneficial dementia (especially Alzheimer’s disease)

As people age, memory and cognitive function slowly decline, and this process is usually very slow, unless there is a sudden stroke, or some kind of injury to the brain, it is not possible to suddenly develop dementia.

Generally, forgetfulness caused by aging and dementia are completely different situations, forgetfulness is occasionally forgotten, but it will be remembered afterwards, and dementia is the frequency of forgetting will increase, even if reminded by others, there is no impression, and even begin to deny that it has happened.

At present, about 60% of the cases of dementia are Alzheimer’s disease, which is a disease in which brain nerve cells gradually die, and even lose cognitive and behavioral abilities in the late stage, requiring people to take care of their daily life.

A double-blind controlled study of 613 patients with mild-to-moderate Alzheimer’s disease over a mean period of 2.3 years found that vitamin E helped slow the progression of clinical symptoms (such as eating, bathing, shopping, and eating) by about 19% compared to taking the drug Memantine (acetylcholinesterase inhibitor) and a placebo. Equivalent to 6.2 months).

Beneficial for seasonal allergic rhinitis

Seasonal allergic rhinitis, also known as hay fever, is a complex condition characterized by runny nose, nasal congestion, sneezing, and nasopharyngeal itching. It is an inflammatory condition of the upper respiratory tract that occurs when sensitizing individuals are exposed to airborne allergens (usually tree, grass, and weed pollen). It affects 30% to 40% of adults and children, and its prevalence is on the rise.

To date, treatment for allergic rhinitis has included avoidance of allergens, medication, and immunotherapy. However, for SAR, avoiding allergens completely may not be desirable, as it may require limiting time spent outdoors.

Therefore, medications, including selective antihistamines, corticosteroids, decongestants, bronchodilators, intranasal mast cell stabilizers, and leukotriene receptor antagonists, are more effective at relieving symptoms than avoiding allergens.

A double-blind controlled study of 112 hay fever patients using conventional treatment found that vitamin E(800 mg daily) further reduced nasal symptoms (e.g., sneezing, nasal congestion, runny nose, and itching) during the hay fever season compared to placebo.

The underlying mechanism is thought to be related to the inhibitory inflammatory response of vitamin E and the production of allergic antibody IgE (immunoglobulin E)

Vitamin E Manufacturer /Vitamin E Manufacturers/Vitamin E Supplier /lutein Suppliers/lutein Factory:

Backvita Biotech, Inc.

Telefon: +86 (029) 8187 2325

() ()