Resveratrol benefits improve fertility in older animals within a week

Resveratrol supplements ，There is a saying in the “health industry” that drinking a glass of red wine before going to bed is good for your health. This claim probably stems from the epidemiological “French paradox,” in which the French who eat a high-calorie, high-cholesterol diet have a lower incidence of cardiovascular disease. One explanation for the “French paradox” is that the French love red wine, some of which protects their cardiovascular health.

resveratrol supplement benefits of resveratrol，Thirty years after the “French paradox” was first proposed, the validity of the “red wine hypothesis” is still debated, and doctors do not recommend that people start drinking simply for its possible health benefits. But Resveratrol (trans resveratrol) in red wine has been shown to have antioxidant and inflammatory effects, but it is found in lower amounts in red wine. More recently, resveratrol was found by Japanese scientists to improve the fertility of older female mice, and the study was published in the journal Aging in July 2022.

Trans resveratrol benefits ，The researchers divided the mice into four groups of 10 and treated them with resveratrol for 0-22 weeks by mixing 0.02% (w/w) of resveratrol into their food. At the end of the treatment, the mice were 47 weeks old (compared to 42 years in humans), making them “advanced maternal age” in mice.

To test the mice’s fertility, the researchers removed and counted the mice’s oocytes and inseminated them in vitro. The fertilized eggs were cultured in vitro for 88 hours, and the resulting embryos were retransplanted back into the mice. After a 19-day gestation period, the researchers performed C-sections on the mice.

The results showed that after feeding with resveratrol, the fertility of the “old born mice” was significantly improved. Although the number of oocytes they expelled did not change significantly, the success rate of embryo transfer and live birth rate were increased by 3-4 times, and the morphology of the fetus and placenta was normal. It is worth noting that it takes only one week of treatment to achieve this effect, which is about half a year in humans, which is a reasonable length of treatment for elderly women in the future.

After further study, it was found that short-term resveratrol treatment increased the activity of mouse oocytes and the production of the cell energy molecule ATP (adenosine triphosphate), which is also believed by the researchers to be one of the reasons for the recovery of fertility in aging mice.

According to the international general medical diagnostic criteria, women who give birth over the age of 35 are classified as “advanced maternal age”, and women over the age of 40 are at further increased risk of giving birth. Now this animal study has confirmed the fertility restoration effect of resveratrol in older female rats, which also gives older women who want to have children the possibility of improving their fertility.

References:

Okamoto, N., Sato, Y., Kawagoe, Y., Shimizu, T., & Kawamura,  K. (2022). Short-term resveratrol treatment restored the quality of oocytes in aging mice. Aging, 14(14),  5628-5640.

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